Article

TIFA Promotes CRC Cell Proliferation via RSK- and PRAS40- Dependent Manner

2021-09-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Previous studies have shown that TIFA (TNF receptor associated factor (TRAF)-interacting protein with a Forkhead-associated (FHA) domain) plays different roles in various tumor types. However, the function of TIFA in colorectal cancer (CRC) remains unclear. The goal of this study is to uncover the biological function and molecular mechanism of TIFA in CRC.<bold>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2be4602c-63ae-5dbd-8640-34be68bf3617
DOI: 10.21203/rs.3.rs-934174/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TIFA Promotes CRC Cell Proliferation via RSK- and PRAS40- Dependent MannerDOI 10.21203/rs.3.rs-934174/v1Read

IFITM2 is a prognostic in colorectal cancer and promotes progression by activating PI3K/AKT pathwaySemantic proximity Read

RAF1 contributes to cell proliferation and STAT3 activation in colorectal cancer independently of microsatellite and KRAS status.Semantic proximity Read

SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitinationSemantic proximity Read

Decreased level of RASSF6 in sporadic colorectal cancer and its anti-tumor effects both in vitro and in vivo.Semantic proximity Read

Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis.Semantic proximity Read

SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitinationSemantic proximity Read

TRAIP functions as an oncogene in hepatocellular carcinoma via Rb/EZH2/p21 signaling pathwaySemantic proximity Read

FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formationSemantic proximity Read

Molecular insight of regorafenib treatment for colorectal cancer.Semantic proximity Read

Predicted miRNAs suppressed cell proliferation and migration via FAK/VASP axis; Systems biology approachSemantic proximity Read

A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cellsSemantic proximity Read

TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/β-catenin degradation and is targeted for GSK3B/GSK3β-mediated phosphorylation and degradationSemantic proximity Read