Article
The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2008
Fernández-Rubio Aida, López-Cima M Felicitas, González-Arriaga Patricia, García-Castro Laura, Pascual Teresa, Marrón Manuel G, Tardón Adonina
Abstract excerpt
SUMMARY: Polymorphisms in tumor suppressor genes might contribute to the individual susceptibility to develop different types of cancer. Alterations in genes involved in cell cycle regulation and apoptosis, as tumor suppressor gene TP53, can lead to malignant transformations increasing the risk of developing cancer. We have investigated effects of polymorphism Arg72Pro on lung cancer risk, focusing on smoking and...
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