Article
Expression of a mutant p53 results in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice.
PloS one - 1 Jan 2009
Duan Wenrui, Gao Li, Wu Xin, Hade Erinn M, Gao Jian-Xin, Ding Haiming, Barsky Sanford H, Otterson Gregory A, Villalona-Calero Miguel A
Abstract excerpt
BACKGROUND: Mutations in the P53 gene are among the most common genetic abnormalities in human lung cancer. Codon 273 in the sequence-specific DNA binding domain is one of the most frequently mutated sites. METHODOLOGY: To investigate the role of mutant p53 in lung tumorigenesis, a lung specific p53(273H) transgenic mouse model was developed. Rates of lung cancer formation in the transgenic animals and their...
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