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Article

Genome-wide functional synergy between amplified and mutated genes in human breast cancer.

Cancer research - 15 Nov 2008

Nikolsky Yuri, Sviridov Evgeny, Yao Jun, Dosymbekov Damir, Ustyansky Vadim, Kaznacheev Valery, Dezso Zoltan, Mulvey Laura, Macconaill Laura E, Winckler Wendy, Serebryiskaya Tatiana, Nikolskaya Tatiana, Polyak Kornelia

Abstract excerpt

A single cancer cell contains large numbers of genetic alterations that in combination create the malignant phenotype. However, whether amplified and mutated genes form functional and physical interaction networks that could explain the selection for cells with combined alterations is unknown. To investigate this issue, we characterized copy number alterations in 191 breast tumors using dense single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19010930
DOI: 10.1158/0008-5472.CAN-08-3082

Genes

ESR1

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