Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis.

American journal of human genetics - 7 Sept 2012

Li Miao-Xin, Kwan Johnny S H, Sham Pak C

Abstract excerpt

The extended Simes' test (known as GATES) and scaled chi-square test were proposed to combine a set of dependent genome-wide association signals at multiple single-nucleotide polymorphisms (SNPs) for assessing the overall significance of association at the gene or pathway levels. The two tests use different strategies to combine association p values and can outperform each other when the number of and linkage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HapMap Project

Share to Polymorphism, Single Nucleotide

Share to Protein Interaction Maps

Source

Open in PubMed Open full text

Identifiers

PMID: 22958900
DOI: 10.1016/j.ajhg.2012.08.004
PMCID: PMC3511992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HYST: a hybrid set-based test for genome-wide association studies, with application to protein-protein interaction-based association analysis.PMID 22958900Read ↗

GATES: a rapid and powerful gene-based association test using extended Simes procedure.Semantic proximity Read ↗

Gene-based testing of interactions in association studies of quantitative traits.Semantic proximity Read ↗

Discovering genetic interactions bridging pathways in genome-wide association studiesSemantic proximity Read ↗

Powerful Set-Based Gene-Environment Interaction Testing Framework for Complex Diseases.Semantic proximity Read ↗

Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data.Semantic proximity Read ↗

Efficient two-step testing of gene-gene interactions in genome-wide association studies.Semantic proximity Read ↗

SBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases.Semantic proximity Read ↗

TATES: efficient multivariate genotype-phenotype analysis for genome-wide association studies.Semantic proximity Read ↗

Gene set analysis of SNP data: benefits, challenges, and future directions.Semantic proximity Read ↗

FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics.Semantic proximity Read ↗

RAPID detection of gene-gene interactions in genome-wide association studies.Semantic proximity Read ↗

dmGWAS: dense module searching for genome-wide association studies in protein-protein interaction networks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.