Article
Functional consequences of the genetic polymorphism of the third component of complement.
The Journal of pediatrics - 1 May 1990
Welch T R, Beischel L, Kleesattel A
Abstract excerpt
The third component of complement, the central protein of the complement cascade, occurs in two principal allotypes, C3S and C3F. An excess frequency of the F allotype has been implicated in a number of disease states, including some forms of glomerulonephritis. These associations have been explained by functional differences between C3S and C3F. We examined several complement functions, using purified...
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