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Article

Proposed structure of the F' allotype of human CR1. Loss of a C3b binding site may be associated with altered function.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1991

Wong W W, Farrell S A

Abstract excerpt

Human CR1 is composed of tandem long homologous repeating (LHR) segments that encode separate binding sites for C3b or C4b. Homologous recombination with unequal crossover has been proposed as the genetic mechanism that gave rise to the CR1 alleles that differed in their total numbers of LHR. The F allotype has four LHR, named LHR-A, -B, -C, -D, 5' to 3'. The site in LHR-A preferentially binds C4b and those in...

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PMID: 1670949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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