Article
Proposed structure of the F' allotype of human CR1. Loss of a C3b binding site may be associated with altered function.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 1991
Wong W W, Farrell S A
Abstract excerpt
Human CR1 is composed of tandem long homologous repeating (LHR) segments that encode separate binding sites for C3b or C4b. Homologous recombination with unequal crossover has been proposed as the genetic mechanism that gave rise to the CR1 alleles that differed in their total numbers of LHR. The...
Topics
- Alleles
- Antigens, CD
- Base Sequence
- Complement C3-C5 Convertases
- Complement C3b
- Complement Pathway, Alternative
- Complement Pathway, Classical
- Humans
- Introns
- Molecular Sequence Data
- Polymorphism, Restriction Fragment Length
- Protein Binding
- Receptors, Complement
- Receptors, Complement 3b
- Recombinant Proteins
- Repetitive Sequences, Nucleic Acid
- Structure-Activity Relationship