Article
Influence of donor C3 allotype on late renal-transplantation outcome.
The New England journal of medicine - 11 May 2006
Brown Katherine M, Kondeatis Elli, Vaughan Robert W, Kon Sui P, Farmer Christopher K T, Taylor John D, He Xiang, Johnston Atholl, Horsfield Catherine, Janssen Bert J C, Gros Piet, Zhou Wuding, Sacks Steven H, Sheerin Neil S
Abstract excerpt
BACKGROUND: The complement system has a critical role in both the innate and the adaptive immune responses. In humans, C3 exists as two main allotypes, F (fast) and S (slow), which are known to affect the incidence of inflammatory disease. We conducted a study to address the influence of these alleles on late renal-graft outcome. METHODS: We determined the C3 allotypes of 662 pairs of adult kidney donors and...
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