Article
High levels of mannose-binding lectin are associated with poor outcomes after lung transplantation.
Transplantation - 15 May 2011
Carroll Katherine E, Dean Melinda M, Heatley Susan L, Meehan Aislin C, Mifsud Nicole A, Kotsimbos Tom C, Snell Greg I, Westall Glen P
Abstract excerpt
BACKGROUND: Mannose-binding lectin (MBL) is a key molecule of the innate immune system and, in addition to the classical and alternative pathways, a principle driver of complement activation. Genetic mutations of MBL are common, result in low serum levels of MBL, and are associated with increased infection risk in solid-organ transplant recipients. METHODS: We performed a retrospective study of MBL2 genotype and...
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