Article
Donor mannose-binding lectin gene polymorphisms influence the outcome of liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Oct 2009
Cervera Carlos, Balderramo Domingo, Suárez Belén, Prieto Jhon, Fuster Francisco, Linares Laura, Fuster Josep, Moreno Asunción, Lozano Francisco, Navasa Miquel
Abstract excerpt
Mannose-binding lectin (MBL) is a C-type lectin produced mainly by the liver that binds to a wide range of pathogens. Polymorphisms at the promoter and exon 1 of the MBL2 gene are responsible for low serum levels of MBL and have been associated with an increased risk of infections. We prospectively analyzed 95 liver transplant recipients. Well-known functionally relevant polymorphisms of the MBL2 gene of the...
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