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Article

Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.

PloS one - 9 Feb 2011

Kauwe John S K, Cruchaga Carlos, Karch Celeste M, Sadler Brooke, Lee Mo, Mayo Kevin, Latu Wayne, Su'a Manti, Fagan Anne M, Holtzman David M, Morris John C, Goate Alison M

Abstract excerpt

Recent genome-wide association studies of Alzheimer's disease (AD) have identified variants in BIN1, CLU, CR1 and PICALM that show replicable association with risk for disease. We have thoroughly sampled common variation in these genes, genotyping 355 variants in over 600 individuals for whom measurements of two AD biomarkers, cerebrospinal fluid (CSF) 42 amino acid amyloid beta fragments (Aβ(42)) and tau...

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Identifiers

PMID: 21347408
DOI: 10.1371/journal.pone.0015918
PMCID: PMC3036586

Genes

BIN1
CLU
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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