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Article

CREBBP mutations in relapsed acute lymphoblastic leukaemia.

Nature - 10 Mar 2011

Mullighan Charles G, Zhang Jinghui, Kasper Lawryn H, Lerach Stephanie, Payne-Turner Debbie, Phillips Letha A, Heatley Sue L, Holmfeldt Linda, Collins-Underwood J Racquel, Ma Jing, Buetow Kenneth H, Pui Ching-Hon, Baker Sharyn D, Brindle Paul K, Downing James R

Abstract excerpt

Relapsed acute lymphoblastic leukaemia (ALL) is a leading cause of death due to disease in young people, but the biological determinants of treatment failure remain poorly understood. Recent genome-wide profiling of structural DNA alterations in ALL have identified multiple submicroscopic somatic mutations targeting key cellular pathways, and have demonstrated substantial evolution in genetic alterations from...

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Topics

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Share to Acetylation
Share to CREB-Binding Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Epigenesis, Genetic

Share to Histone Acetyltransferases

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Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Source

Open in PubMed Open full text

Identifiers

PMID: 21390130
DOI: 10.1038/nature09727
PMCID: PMC3076610

Genes

CREBBP
CTCF
ERG
NCOR1
SPI1
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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