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Article

CREBBP mutations in relapsed acute lymphoblastic leukaemia.

Nature - 10 Mar 2011

Mullighan Charles G, Zhang Jinghui, Kasper Lawryn H, Lerach Stephanie, Payne-Turner Debbie, Phillips Letha A, Heatley Sue L, Holmfeldt Linda, Collins-Underwood J Racquel, Ma Jing, Buetow Kenneth H, Pui Ching-Hon, Baker Sharyn D, Brindle Paul K, Downing James R

Abstract excerpt

Relapsed acute lymphoblastic leukaemia (ALL) is a leading cause of death due to disease in young people, but the biological determinants of treatment failure remain poorly understood. Recent genome-wide profiling of structural DNA alterations in ALL have identified multiple submicroscopic somatic mutations targeting key cellular pathways, and have demonstrated substantial evolution in genetic alterations from...

Topics

Acetylation
CREB-Binding Protein
Drug Resistance, Neoplasm
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Histone Acetyltransferases
Histones
Humans
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

Recurrence

Source

Open in PubMed Open full text

Identifiers

PMID: 21390130
DOI: 10.1038/nature09727
PMCID: PMC3076610

Genes

CREBBP
CTCF
ERG
NCOR1
SPI1
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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