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Article

Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression.

The Journal of biological chemistry - 13 Apr 2007

Girnita Leonard, Shenoy Sudha K, Sehat Bita, Vasilcanu Radu, Vasilcanu Daiana, Girnita Ada, Lefkowitz Robert J, Larsson Olle

Abstract excerpt

Beta-arrestin1, which regulates many aspects of seven transmembrane receptor (7TMR) biology, has also been shown to serve as an adaptor, which brings Mdm2, an E3 ubiquitin ligase to the insulin-like growth factor-1 receptor (IGF-1R), leading to its proteasome-dependent destruction. Here we demonstrate that IGF-1R stimulation also leads to ubiquitination of beta-arrestin1, which regulates vesicular trafficking and...

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Identifiers

PMID: 17303558
DOI: 10.1074/jbc.M611526200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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