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Article

Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.

PLoS medicine - 1 Feb 2006

Barreiro Luis B, Neyrolles Olivier, Babb Chantal L, Tailleux Ludovic, Quach Hélène, McElreavey Ken, Helden Paul D van, Hoal Eileen G, Gicquel Brigitte, Quintana-Murci Lluis

Abstract excerpt

BACKGROUND: Tuberculosis, which is caused by Mycobacterium tuberculosis, remains one of the leading causes of mortality worldwide. The C-type lectin DC-SIGN is known to be the major M. tuberculosis receptor on human dendritic cells. We reasoned that if DC-SIGN interacts with M. tuberculosis, as well as with other pathogens, variation in this gene might have a broad range of influence in the pathogenesis of a...

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Identifiers

PMID: 16379498
DOI: 10.1371/journal.pmed.0030020
PMCID: PMC1324949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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