Article
Genetic signatures of high-altitude adaptation in Tibetans.
Proceedings of the National Academy of Sciences of the United States of America - 18 Apr 2017
Yang Jian, Jin Zi-Bing, Chen Jie, Huang Xiu-Feng, Li Xiao-Man, Liang Yuan-Bo, Mao Jian-Yang, Chen Xin, Zheng Zhili, Bakshi Andrew, Zheng Dong-Dong, Zheng Mei-Qin, Wray Naomi R, Visscher Peter M, Lu Fan, Qu Jia
Abstract excerpt
Indigenous Tibetan people have lived on the Tibetan Plateau for millennia. There is a long-standing question about the genetic basis of high-altitude adaptation in Tibetans. We conduct a genome-wide study of 7.3 million genotyped and imputed SNPs of 3,008 Tibetans and 7,287 non-Tibetan individuals of Eastern Asian ancestry. Using this large dataset, we detect signals of high-altitude adaptation at nine genomic...
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