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Article

Maternal diet and aging alter the epigenetic control of a promoter–enhancer interaction at the <i>Hnf4a</i> gene in rat pancreatic islets

8 Mar 2011

Abstract excerpt

Environmental factors interact with the genome throughout life to determine gene expression and, consequently, tissue function and disease risk. One such factor that is known to play an important role in determining long-term metabolic health is diet during critical periods of development. Epigenetic regulation of gene expression has been implicated in mediating these programming effects of early diet. The...

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Share to Epigenetics and DNA Methylation
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PMID: 21385945
DOI: 10.1073/pnas.1019007108

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