Article
A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes.
Diabetes - 1 Jun 2006
Ek Jakob, Hansen Sara P, Lajer Maria, Nicot Carine, Boesgaard Trine W, Pruhova Stepanka, Johansen Anders, Albrechtsen Anders, Yderstraede Knud, Lauenborg Jeannet, Parrizas Marcelina, Boj Sylvia F, Jørgensen Torben, Borch-Johnsen Knut, Damm Peter, Ferrer Jorge, Lebl Jan, Pedersen Oluf, Hansen Torben
Abstract excerpt
Recently, it has been shown that mutations in the P2 promoter of the hepatocyte nuclear factor (HNF)-4 alpha gene (HNF4A) cause maturity-onset diabetes of the young (MODY), while single nucleotide polymorphisms in this locus are associated with type 2 diabetes. In this study, we examined 1,189 bp of the P2 promoter and the associated exon 1D of HNF4A for variations associated with diabetes in 114 patients with...
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