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Article

Hepatocyte nuclear factor 4alpha contributes to an intestinal epithelial phenotype in vitro and plays a partial role in mouse intestinal epithelium differentiation.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2009

Babeu Jean-Philippe, Darsigny Mathieu, Lussier Carine R, Boudreau François

Abstract excerpt

Hepatocyte nuclear factor 4alpha (HNF4alpha) is a regulator of hepatocyte and pancreatic transcription. Hnf4alpha deletion in the mouse is embryonically lethal with severe defects in visceral endoderm formation. It has been concluded in the past that the role of Hnf4alpha in the developing colon was much less important than in the liver. However, the precise role of Hnf4alpha in the homeostasis of the small...

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PMID: 19389805
DOI: 10.1152/ajpgi.90690.2008

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