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Article

Epigenetic control of EMT/MET dynamics: HNF4α impacts DNMT3s through miRs-29

21 May 2015

Abstract excerpt

BACKGROUND AND AIMS: Epithelial-to-mesenchymal transition (EMT) and the reverse mesenchymal-to-epithelial transition (MET) are manifestations of cellular plasticity that imply a dynamic and profound gene expression reprogramming. While a major epigenetic code controlling the coordinated regulation of a whole transcriptional profile is guaranteed by DNA methylation, DNA methyltransferase (DNMT) activities in...

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PMID: 26003733
DOI: 10.1016/j.bbagrm.2015.05.005

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