Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell lineage dynamics in the process leading to intestinal metaplasia.

Journal of gastroenterology - 1 May 2011

Sakamoto Hirotsugu, Mutoh Hiroyuki, Hayakawa Hiroko, Sashikawa Miho, Sugano Kentaro

Abstract excerpt

BACKGROUND: Gene expression in the early stage of the transition to intestinal metaplasia in human gastric mucosa has not been determined. In this study, we investigated the temporal relationship between cell lineage changes and intestine-specific gene expression in the process leading to intestinal metaplasia, using Cdx2-transgenic mice. METHODS: Cellular phenotypes were analyzed by immunohistochemistry and were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDX2 Transcription Factor
Share to Cell Lineage
Share to Cell Transdifferentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastric Mucosa

Share to Homeodomain Proteins

Share to Intestinal Mucosa

Share to Metaplasia

Share to Trans-Activators

Source

Identifiers

PMID: 21384254
DOI: 10.1007/s00535-011-0391-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell lineage dynamics in the process leading to intestinal metaplasia.PMID 21384254Read ↗

Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration.Semantic proximity Read ↗

Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic miceSemantic proximity Read ↗

Gastric-and-intestinal mixed-type intestinal metaplasia: aberrant expression of transcription factors and stem cell intestinalization.Semantic proximity Read ↗

CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cellsSemantic proximity Read ↗

CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.Semantic proximity Read ↗

Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa.Semantic proximity Read ↗

Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice.Semantic proximity Read ↗

The Molecular Pathogenesis of Barrett’s Esophagus: Common Signaling Pathways in Embryogenesis Metaplasia and NeoplasiaSemantic proximity Read ↗

Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells.Semantic proximity Read ↗

A pSMAD/CDX2 Complex Is Essential for the Intestinalization of Epithelial MetaplasiaSemantic proximity Read ↗

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotypeSemantic proximity Read ↗

Isthmus Stem Cells Are the Origins of Metaplasia in the Gastric CorpusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.