Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.

The Journal of clinical investigation - 1 Apr 2011

Connell Claire M, Shibata Atsushi, Tookman Laura A, Archibald Kyra M, Flak Magdalena B, Pirlo Katrina J, Lockley Michelle, Wheatley Sally P, McNeish Iain A

Abstract excerpt

Oncolytic adenoviruses replicate selectively within and lyse malignant cells. As such, they are being developed as anticancer therapeutics. However, the sensitivity of ovarian cancers to adenovirus cytotoxicity varies greatly, even in cells of similar infectivity. Using both the adenovirus E1A-CR2 deletion mutant dl922-947 and WT adenovirus serotype 5 in a panel of human ovarian cancer cell lines that cover a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to cdc25 Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Checkpoint Kinase 1

Share to Mice, Nude

Share to Neoplasm Transplantation

Share to Oncolytic Virotherapy

Share to Oncolytic Viruses

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 21383502
DOI: 10.1172/JCI43976
PMCID: PMC3069766

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells.PMID 21383502Read ↗

CDK2 regulates collapsed replication fork repair in CCNE1-amplified ovarian cancer cells via homologous recombinationSemantic proximity Read ↗

Adenovirus and cell cycle controlSemantic proximity Read ↗

Inhibition of MEK-ERK pathway enhances oncolytic vaccinia virus replication in doxorubicin-resistant ovarian cancerSemantic proximity Read ↗

AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response ProteinsSemantic proximity Read ↗

Exploiting replicative stress in gynecological cancers as a therapeutic strategySemantic proximity Read ↗

Combining Oncolytic Adenovirus with Radiation—A Paradigm for the Future of RadiosensitizationSemantic proximity Read ↗

SARS-CoV-2 triggers DNA damage response in Vero E6 cellsSemantic proximity Read ↗

Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral ReplicationSemantic proximity Read ↗

The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response.Semantic proximity Read ↗

A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses.Semantic proximity Read ↗

Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.Semantic proximity Read ↗

Viral Transport of DNA Damage That Mimics a Stalled Replication ForkSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.