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Article

A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2005

Wang Yaohe, Thorne Stephen, Hannock Joseph, Francis Jennelle, Au Tina, Reid Tony, Lemoine Nick, Kirn David, Halldén Gunnel

Abstract excerpt

PURPOSE: Replication-selective oncolytic adenoviruses hold promise for cancer treatment, but the predictive use of cell lines, dissociated tumor tissue, and animal models for efficacy against primary cancers are unclear. To further evaluate cytotoxicity and the potential for efficacy of replication-competent adenoviruses we therefore developed a novel methodology using primary human cancer specimens ex vivo;...

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Share to Adenoviridae
Share to Adenovirus E1A Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytopathogenic Effect, Viral

Share to Gene Expression Regulation, Viral

Share to Genetic Techniques

Share to Proliferating Cell Nuclear Antigen

Share to Receptors, Virus

Share to Virus Replication

Source

Identifiers

PMID: 15671566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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