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Article

Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage.

Molecular cell - 14 Aug 2009

Johnson Neil, Cai Dongpo, Kennedy Richard D, Pathania Shailja, Arora Mansi, Li Yu-Chen, D'Andrea Alan D, Parvin Jeffrey D, Shapiro Geoffrey I

Abstract excerpt

Cdk2 and cdk1 are individually dispensable for cell-cycle progression in cancer cell lines because they are able to compensate for one another. However, shRNA-mediated depletion of cdk1 alone or small molecule cdk1 inhibition abrogated S phase cell-cycle arrest and the phosphorylation of a subset of ATR/ATM targets after DNA damage. Loss of DNA damage-induced checkpoint control was caused by a reduction in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19683496
DOI: 10.1016/j.molcel.2009.06.036
PMCID: PMC3024055

Genes

BRCA1
ATM
ATR

Provenance

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