Article

AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response Proteins

2025-10-15

Abstract excerpt

Recombinant adeno-associated virus (rAAV) is a replication-defective viral vector used in hundreds of human gene therapy trials, resulting in five FDA-approved therapies. Despite this success, rAAV-based gene therapies suffer from dose-limiting toxicities, resulting in several severe adverse reactions, including death. Previously, we discovered that rAAV rapidly kills mouse NPCs in vitro and in vivo. This vector c...

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Literature Corpus work: 722e9f49-7a2c-5544-b07e-933cc2069e4c
DOI: 10.1101/2025.10.14.682484

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AAV Kills Dividing Cells by Depleting PARP1 and Other DNA Damage Response ProteinsDOI 10.1101/2025.10.14.682484Read

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