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Viral Transport of DNA Damage That Mimics a Stalled Replication Fork

16 Dec 2004

Abstract excerpt

Adeno-associated virus type 2 (AAV2) infection incites cells to arrest with 4N DNA content or die if the p53 pathway is defective. This arrest depends on AAV2 DNA, which is single stranded with inverted terminal repeats that serve as primers during viral DNA replication. Here, we show that AAV2 DNA triggers damage signaling that resembles the response to an aberrant cellular DNA replication fork. UV treatment of...

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Identifiers

PMID: 15596849
DOI: 10.1128/jvi.79.1.569-580.2005

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