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Article

LNA-mediated anti–miR-155 silencing in low-grade B-cell lymphomas

14 Jul 2012

Abstract excerpt

miR-155 acts as an oncogenic miR in B-cell lymphoproliferative disorders, including Waldenstrom macroglobulinemia (WM) and chronic lymphocytic leukemia, and is therefore a potential target for therapeutic intervention. However, efficient targeting of miRs in tumor cells in vivo remains a significant challenge for the development of miR-155-based therapeutics for the treatment of B-cell malignancies. In the...

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PMID: 22797699
DOI: 10.1182/blood-2012-02-410647

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