Article
Oncogenic role of microRNA-155 in mycosis fungoides: an in vitro and xenograft mouse model study.
The British journal of dermatology - 1 Sept 2017
Moyal L, Yehezkel S, Gorovitz B, Keren A, Gilhar A, Lubin I, Sherman S, Hodak E
Abstract excerpt
BACKGROUND: MicroRNA (miR)-155 contributes to the proliferation of mycosis fungoides (MF) in vitro and is upregulated in tumours of MF compared with early MF lesions. OBJECTIVES: To investigate the contribution of miR-155 to the cancerous phenotype and drug resistance of MF/Sézary cell lines. METHODS: miR-155 was inhibited in MF cell lines (MyLa and MJ) by transduction of miRZip anti-miR-155, and overexpressed in...
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