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Article

A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner.

Immunity - 21 Jul 2015

Lu Li-Fan, Gasteiger Georg, Yu I-Shing, Chaudhry Ashutosh, Hsin Jing-Ping, Lu Yuheng, Bos Paula D, Lin Ling-Li, Zawislak Carolyn L, Cho Sunglim, Sun Joseph C, Leslie Christina S, Lin Shu-Wha, Rudensky Alexander Y

Abstract excerpt

MicroRNA (miRNA)-dependent regulation of gene expression confers robustness to cellular phenotypes and controls responses to extracellular stimuli. Although a single miRNA can regulate expression of hundreds of target genes, it is unclear whether any of its distinct biological functions can be due to the regulation of a single target. To explore in vivo the function of a single miRNA-mRNA interaction, we mutated...

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Share to Encephalomyelitis, Autoimmune, Experimental
Share to Herpesviridae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Lymphocytic choriomeningitis virus

Share to Muromegalovirus

Share to Suppressor of Cytokine Signaling 1 Protein

Share to Suppressor of Cytokine Signaling Proteins

Share to T-Lymphocytes, Regulatory

Source

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Identifiers

PMID: 26163372
DOI: 10.1016/j.immuni.2015.04.022
PMCID: PMC4529747

Genes

SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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