Prognostic relevance of miRNA-155 methylation in anaplastic glioma.

doi:10.18632/oncotarget.13452

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Article

Prognostic relevance of miRNA-155 methylation in anaplastic glioma.

Oncotarget - 13 Dec 2016

Schliesser Maximilian Georg, Claus Rainer, Hielscher Thomas, Grimm Christiane, Weichenhan Dieter, Blaes Jonas, Wiestler Benedikt, Hau Peter, Schramm Johannes, Sahm Felix, Weiß Elisa K, Weiler Markus, Baer Constance, Schmidt-Graf Friederike, Schackert Gabriele, Westphal Manfred, Hertenstein Anne, Roth Patrick, Galldiks Norbert, Hartmann Christian, Pietsch Torsten, Felsberg Joerg, Reifenberger Guido, Sabel Michael Christoph, Winkler Frank, von Deimling Andreas, Meisner Christoph, Vajkoczy Peter, Platten Michael, Weller Michael, Plass Christoph, Wick Wolfgang

Abstract excerpt

The outcome of patients with anaplastic gliomas varies considerably depending on single molecular markers, such as mutations of the isocitrate dehydrogenase (IDH) genes, as well as molecular classifications based on epigenetic or genetic profiles. Remarkably, 98% of the RNA within a cell is not translated into proteins. Of those, especially microRNAs (miRNAs) have been shown not only to have a major influence on...

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PMID: 27880937
DOI: 10.18632/oncotarget.13452
PMCID: PMC5347671

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