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Article

In situ analysis ofLKB1/STK11 mRNA expression in human normal tissues and tumours

1 Jan 2000

Abstract excerpt

The LKB1/STK11 serine/threonine kinase is mutated in Peutz-Jeghers' syndrome and acts as a tumour suppressor. Using northern blotting and RT-PCR, LKB1 has been reported to be expressed widely in human adult tissues, although in Xenopus the expression of its homologue, XEEK1, is apparently restricted to early embryogenesis. In situ hybridization has been used to detect and localize LKB1 mRNA in a variety of adult...

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PMID: 11004696
DOI: 10.1002/1096-9896(2000)9999:9999<::aid-path686>3.0.co;2-j

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