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Article

Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas.

European journal of cancer (Oxford, England : 1990) - 1 Jan 2004

Kim C J, Cho Y G, Park J Y, Kim T Y, Lee J H, Kim H S, Lee J W, Song Y H, Nam S W, Lee S H, Yoo N J, Lee J Y, Park W S

Abstract excerpt

The tumour suppressor gene, LKB1/STK11, has been mapped to chromosome 19p13, a region showing frequent allelic loss in various human cancers, including hepatocellular carcinoma (HCC). Additionally, LKB1 physically associates with p53 and regulates p53-dependent apoptotic pathways. To investigate whether genetic alterations of LKB1 could be involved in the tumorigenesis of HCC, we analysed the genetic alterations...

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Share to AMP-Activated Protein Kinase Kinases
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Codon, Nonsense

Share to Genes, p53

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Share to Loss of Heterozygosity

Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 14687797
DOI: 10.1016/s0959-8049(03)00659-2

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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