Article
Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic β-cell function over 5 years of follow-up.
Diabetes - 1 Oct 2013
Andersson Ehm A, Allin Kristine H, Sandholt Camilla H, Borglykke Anders, Lau Cathrine J, Ribel-Madsen Rasmus, Sparsø Thomas, Justesen Johanne M, Harder Marie N, Jørgensen Marit E, Jørgensen Torben, Hansen Torben, Pedersen Oluf
Abstract excerpt
More than 40 genetic risk variants for type 2 diabetes have been validated. We aimed to test whether a genetic risk score associates with the incidence of type 2 diabetes and with 5-year changes in glycemic traits and whether the effects were modulated by changes in BMI and lifestyle. The Inter99 study population was genotyped for 46 variants, and a genetic risk score was constructed. During a median follow-up of...
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