Article
Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants.
Diabetes - 1 Feb 2016
Hivert Marie-France, Christophi Costas A, Franks Paul W, Jablonski Kathleen A, Ehrmann David A, Kahn Steven E, Horton Edward S, Pollin Toni I, Mather Kieren J, Perreault Leigh, Barrett-Connor Elizabeth, Knowler William C, Florez Jose C
Abstract excerpt
Large genome-wide association studies of glycemic traits have identified genetics variants that are associated with insulin resistance (IR) in the general population. It is unknown whether people with genetic enrichment for these IR variants respond differently to interventions that aim to improve insulin sensitivity. We built a genetic risk score (GRS) based on 17 established IR variants and effect sizes...
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