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Article

Nucleotide and haplotypic diversity of the NOS2A promoter region and its relationship to cerebral malaria.

Human genetics - 1 Apr 2003

Burgner David, Usen Stanley, Rockett Kirk, Jallow Muminatou, Ackerman Hans, Cervino Alessandra, Pinder Margaret, Kwiatkowski Dominic P

Abstract excerpt

To assess the hypothesis that nitric oxide is critical in the pathogenesis of cerebral malaria, we analysed genetic variation in the proximal promoter region of NOS2A, the gene encoding inducible nitric oxide synthase. Sequencing 72 Gambian chromosomes revealed 11 single nucleotide polymorphisms in 2.5 kB (theta=8.6 x 10(-4)). Genotyping 104 nuclear families identified six common haplotypes. A single haplotype,...

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PMID: 12552317
DOI: 10.1007/s00439-002-0882-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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