Article
Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells.
Gastroenterology - 1 Jun 2011
Pinchuk Irina V, Beswick Ellen J, Saada Jamal I, Boya Gushyalatha, Schmitt David, Raju Gottumukkala S, Brenmoehl Julia, Rogler Gerhard, Reyes Victor E, Powell Don W
Abstract excerpt
BACKGROUND & AIMS: Regulatory T (Treg) cells (CD4+ CD25high FoxP3+) regulate mucosal tolerance; their adoptive transfer prevents or reduces symptoms of colitis in mouse models of inflammatory bowel disease. Colonic CD90+ mesenchymal myofibroblasts and fibroblasts (CMFs) are abundant, nonprofessional antigen-presenting cells in the normal human colonic mucosa that suppress proliferation of activated CD4+ effector...
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