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Article

PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity.

Gastroenterology - 1 Oct 2008

Pinchuk Irina V, Saada Jamal I, Beswick Ellen J, Boya Gushyalatha, Qiu Sumin M, Mifflin Randy C, Raju Gottumukkala S, Reyes Victor E, Powell Don W

Abstract excerpt

BACKGROUND & AIMS: A prominent role for inhibitory molecules PD-L1 and PD-L2 in peripheral tolerance has been proposed. However, the phenotype and function of PD-L-expressing cells in human gut remains unclear. Recent studies suggest that colonic myofibroblasts (CMFs) and fibroblasts are important in the switch from acute inflammation to adaptive immunity. In the normal human colon, CMFs represent a distinct...

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Identifiers

PMID: 18760278
DOI: 10.1053/j.gastro.2008.07.016
PMCID: PMC2584612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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