Article
Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity.
Inflammatory bowel diseases - 1 Jun 2006
Holmén Nathalie, Lundgren Anna, Lundin Samuel, Bergin Ann-Marie, Rudin Anna, Sjövall Henrik, Ohman Lena
Abstract excerpt
BACKGROUND: Factors determining the extension and degree of inflammation in the colonic mucosa of patients with ulcerative colitis (UC) are largely unknown, but CD4+CD25high regulatory T cells (Tregs) have been implicated to play an important role in suppressing inflammation. Therefore, the aims of this study were to determine whether colonic Tregs have suppressive effects on colonic effector T cells in UC and to...
Topics
- Adult
- Aged
- Biopsy
- Colitis, Ulcerative
- Colon
- Female
- Humans
- Intestinal Mucosa
- Male
- Middle Aged
- Phenotype