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Article

Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Wei Zelan, Gabriel Geraldine G, Rui Lewei, Cao Xia, Pennington Paul R, Chlan-Fourney Jennifer, Nazarali Adil J, Baker Glen B, Mousseau Darrell D

Abstract excerpt

The concentration of presenilin-1 (PS-1) protein at the mitochondrial-associated aspect of the endoplasmic reticulum supports the potential for a mitochondrial influence of PS-1. Given that carriers of certain Alzheimer's disease (AD)-related PS-1 variants are predisposed to clinical depression and that depression has been historically associated with the mitochondrial enzyme, monoamine oxidase-A (MAO-A), we...

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Identifiers

PMID: 22045496
DOI: 10.3233/JAD-2011-111241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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