The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease.

doi:10.1002/ana.410380415

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Article

The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease.

Annals of neurology - 1 Oct 1995

Chen X, Xia Y, Alford M, DeTeresa R, Hansen L, Klauber M R, Katzman R, Thal L, Masliah E, Saitoh T

Abstract excerpt

Both genetic and environmental factors affect the progression of Alzheimer's disease (AD). The presence of cortical Lewy bodies in AD patients is associated with an altered presentation of AD pathology suggestive of an interaction between the pathogenesis of Lewy bodies and AD lesions. Since the...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Brain
Choline O-Acetyltransferase
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Genotype
Humans
Mixed Function Oxygenases

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