Article
The CYP2D6B allele is associated with a milder synaptic pathology in Alzheimer's disease.
Annals of neurology - 1 Oct 1995
Chen X, Xia Y, Alford M, DeTeresa R, Hansen L, Klauber M R, Katzman R, Thal L, Masliah E, Saitoh T
Abstract excerpt
Both genetic and environmental factors affect the progression of Alzheimer's disease (AD). The presence of cortical Lewy bodies in AD patients is associated with an altered presentation of AD pathology suggestive of an interaction between the pathogenesis of Lewy bodies and AD lesions. Since the CYP2D6B mutant allele is often present in patients with Lewy body diseases (Parkinson's disease and Lewy body variant...
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