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Article

Smoking Related Diseases: The Central Role of Monoamine Oxidase

14 Jan 2011

Abstract excerpt

Smoking is a major risk factor of morbidity and mortality. It is well established that monoamine oxidase (MAO) activity is decreased in smokers. Serotonin (5-HT), a major substrate for MAO that circulates as a reserve pool stored in platelets, is a marker of platelet activation. We recently reported that smoking durably modifies the platelet 5-HT/MAO system by inducing a demethylation of the MAO gene promoter...

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PMID: 21318020
DOI: 10.3390/ijerph8010136

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