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Article

Acetylcholinesterase modulates presenilin-1 levels and γ-secretase activity.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Campanari Maria-Letizia, García-Ayllón María-Salud, Belbin Olivia, Galcerán Joan, Lleó Alberto, Sáez-Valero Javier

Abstract excerpt

The cholinergic enzyme acetylcholinesterase (AChE) and the catalytic component of the γ-secretase complex, presenilin-1 (PS1), are known to interact. In this study, we investigate the consequences of AChE-PS1 interactions, particularly the influence of AChE in PS1 levels and γ-secretase activity. PS1 is able to co-immunoprecipitate all AChE variants (AChE-R and AChE-T) and molecular forms (tetramers and light...

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Identifiers

PMID: 24699279
DOI: 10.3233/JAD-140426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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