Article
Increased detection of the HIV-1 reverse transcriptase M184V mutation using mutation-specific minority assays in a UK surveillance study suggests evidence of unrecognized transmitted drug resistance.
HIV medicine - 1 Apr 2011
Buckton A J, Prabhu D, Motamed C, Harris R J, Hill C, Murphy G, Parry J V, Johnson J A, Lowndes C M, Gill N, Pillay D, Cane P A
Abstract excerpt
OBJECTIVES: The aim of the study was to estimate the levels of transmitted drug resistance (TDR) in HIV-1 using very sensitive assays to detect minority drug-resistant populations. METHODS: We tested unlinked anonymous serum specimens from sexual health clinic attendees, who had not received an HIV diagnosis at the time of sampling, by both standard genotyping and using minority detection assays. RESULTS: By...
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