Article
A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 2011
Kao Aimee W, Eisenhut Robin J, Martens Lauren Herl, Nakamura Ayumi, Huang Anne, Bagley Josh A, Zhou Ping, de Luis Alberto, Neukomm Lukas J, Cabello Juan, Farese Robert V, Kenyon Cynthia
Abstract excerpt
Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the second most common cause of early-onset dementia. Mutations in the progranulin gene are a major cause of familial frontotemporal lobar degeneration [Baker M, et al. (2006) Nature 442:916-919 and Cruts M, et al. (2006) Nature 442:920-924]. Although progranulin is involved in wound healing, inflammation, and tumor growth, its...
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