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Article

Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF).

Molecular carcinogenesis - 1 Aug 2017

Vancauwenberghe Eric, Noyer Lucile, Derouiche Sandra, Lemonnier Loïc, Gosset Pierre, Sadofsky Laura R, Mariot Pascal, Warnier Marine, Bokhobza Alexandre, Slomianny Christian, Mauroy Brigitte, Bonnal Jean-Louis, Dewailly Etienne, Delcourt Philippe, Allart Laurent, Desruelles Emilie, Prevarskaya Natalia, Roudbaraki Morad

Abstract excerpt

Previous studies showed the effects of resveratrol (RES) on several cancer cells, including prostate cancer (PCa) cell apoptosis without taking into consideration the impact of the tumor microenvironment (TME). The TME is composed of cancer cells, endothelial cells, blood cells, and cancer-associated fibroblasts (CAF), the main source of growth factors. The latter cells might modify in the TME the impact of RES...

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Identifiers

PMID: 28277613
DOI: 10.1002/mc.22642

Genes

TRPA1
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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