Article
TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014
Raphaël Maylis, Lehen'kyi V'yacheslav, Vandenberghe Matthieu, Beck Benjamin, Khalimonchyk Sergiy, Vanden Abeele Fabien, Farsetti Leonardo, Germain Emmanuelle, Bokhobza Alexandre, Mihalache Adriana, Gosset Pierre, Romanin Christoph, Clézardin Philippe, Skryma Roman, Prevarskaya Natalia
Abstract excerpt
Transient receptor potential vanilloid subfamily member 6 (TRPV6) is a highly selective calcium channel that has been considered as a part of store-operated calcium entry (SOCE). Despite its first discovery in the early 2000s, the role of this channel in prostate cancer (PCa) remained, until now, obscure. Here we show that TRPV6 mediates calcium entry, which is highly increased in PCa due to the remodeling...
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