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Article

Functional variants of the HMGA1 gene and type 2 diabetes mellitus.

JAMA - 2 Mar 2011

Chiefari Eusebio, Tanyolaç Sinan, Paonessa Francesco, Pullinger Clive R, Capula Carmelo, Iiritano Stefania, Mazza Tommaso, Forlin Michele, Fusco Alfredo, Durlach Vincent, Durlach Anne, Malloy Mary J, Kane John P, Heiner Steven W, Filocamo Mirella, Foti Daniela P, Goldfine Ira D, Brunetti Antonio

Abstract excerpt

CONTEXT: High-mobility group A1 (HMGA1) protein is a key regulator of insulin receptor (INSR) gene expression. We previously identified a functional HMGA1 gene variant in 2 insulin-resistant patients with decreased INSR expression and type 2 diabetes mellitus (DM). OBJECTIVE: To examine the association of HMGA1 gene variants with type 2 DM. DESIGN, SETTINGS, AND PARTICIPANTS: Case-control study that analyzed the...

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Identifiers

PMID: 21364139
DOI: 10.1001/jama.2011.207

Genes

HMGA1
INSR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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