Article
Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.
Nature medicine - 1 Jul 2005
Foti Daniela, Chiefari Eusebio, Fedele Monica, Iuliano Rodolfo, Brunetti Leonardo, Paonessa Francesco, Manfioletti Guidalberto, Barbetti Fabrizio, Brunetti Arturo, Croce Carlo M, Fusco Alfredo, Brunetti Antonio
Abstract excerpt
Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally. Although genetics and environmental factors seem to have a role, the cause of this metabolic disorder is largely unknown. Here we report a genetic flaw that markedly reduced the intracellular expression of the high mobility group A1 (HMGA1) protein, and adversely affected insulin receptor expression in cells and tissues from...
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