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Article

Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.

Nature medicine - 1 Jul 2005

Foti Daniela, Chiefari Eusebio, Fedele Monica, Iuliano Rodolfo, Brunetti Leonardo, Paonessa Francesco, Manfioletti Guidalberto, Barbetti Fabrizio, Brunetti Arturo, Croce Carlo M, Fusco Alfredo, Brunetti Antonio

Abstract excerpt

Type 2 diabetes mellitus is a widespread disease, affecting millions of people globally. Although genetics and environmental factors seem to have a role, the cause of this metabolic disorder is largely unknown. Here we report a genetic flaw that markedly reduced the intracellular expression of th...

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Topics

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Share to Glucose Transporter Type 4
Share to Insulin-Like Growth Factor Binding Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor Binding Proteins

Share to Insulin Secretion

Share to Monosaccharide Transport Proteins

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Share to Receptor, Insulin

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Source

Identifiers

PMID: 15924147
DOI: 10.1038/nm1254

Genes

HMGA1
INSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15924147-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice.PMID 15924147Read ↗

Recent advances in the molecular genetics of type 2 diabetes mellitusSemantic proximity Read ↗

Functional variants of the HMGA1 gene and type 2 diabetes mellitus.Semantic proximity Read ↗

Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta CellsSemantic proximity Read ↗

Hyperinsulinemia promotes HMGB1 release leading to inflammation induced systemic insulin resistance: An interplay between pancreatic beta-cell and peripheral organsSemantic proximity Read ↗

Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population.Semantic proximity Read ↗

Epigenomic and transcriptional control of insulin resistanceSemantic proximity Read ↗

High mobility group box 1 (HMGB1) phenotypic role revealed with stress.Semantic proximity Read ↗

High Mobility Group Box 1 (HMGB1): Molecular Signaling and Potential Therapeutic StrategiesSemantic proximity Read ↗

High Mobility Group Box-1: A Missing Link between Diabetes and Its ComplicationsSemantic proximity Read ↗

An integrative transcriptional logic model of hepatic insulin resistanceSemantic proximity Read ↗

A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components.Semantic proximity Read ↗

Transcriptomic analysis of human and mouse muscle during hyperinsulinemia demonstrates insulin receptor downregulation as a mechanism for insulin resistanceSemantic proximity Read ↗

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