Article
A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components.
Scientific reports - 1 Jan 2013
Chiefari Eusebio, Tanyolaç Sinan, Iiritano Stefania, Sciacqua Angela, Capula Carmelo, Arcidiacono Biagio, Nocera Aurora, Possidente Katiuscia, Baudi Francesco, Ventura Valeria, Brunetti Giuseppe, Brunetti Francesco S, Vero Raffaella, Maio Raffaele, Greco Manfredi, Pavia Maria, Hodoglugil Ugur, Durlach Vincent, Pullinger Clive R, Goldfine Ira D, Perticone Francesco, Foti Daniela, Brunetti Antonio
Abstract excerpt
The metabolic syndrome (MetS) is a common disorder, where systemic insulin-resistance is associated with increased risk for type 2 diabetes (T2D) and cardiovascular disease. Identifying genetic traits influencing risk and progression of MetS is important. We and others previously reported a functional HMGA1 gene variant, rs146052672, predisposing to T2D. Here we investigated the association of rs146052672 variant...
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