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Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta Cells

13 Jan 2015

Abstract excerpt

The high-mobility group AT-hook 1 (HMGA1) protein is a nuclear architectural factor that can organize chromatin structures. It regulates gene expression by controlling the formation of stereospecific multiprotein complexes called "enhanceosomes" on the AT-rich regions of target gene promoters. Previously, we reported that defects in HMGA1 caused decreased insulin receptor expression and increased susceptibility...

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Identifiers

PMID: 25628604
DOI: 10.3389/fendo.2014.00237

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Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta CellsPMID 25628604Read ↗

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The Krüppel-Like Protein Gli-Similar 3 (Glis3) Functions as a Key Regulator of Insulin TranscriptionSemantic proximity Read ↗

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