Article
Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk.
Diabetes - 1 Feb 2012
Marquez Marcel, Huyvaert Marlène, Perry John R B, Pearson Richard D, Falchi Mario, Morris Andrew P, Vivequin Sidonie, Lobbens Stéphane, Yengo Loïc, Gaget Stefan, Pattou Francois, Poulain-Godefroy Odile, Charpentier Guillaume, Carlsson Lena M S, Jacobson Peter, Sjöström Lars, Lantieri Olivier, Heude Barbara, Walley Andrew, Balkau Beverley, Marre Michel, Froguel Philippe, Cauchi Stéphane
Abstract excerpt
It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group A1 (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk. In our study, we attempted to confirm that HMGA1 is a novel type 2 diabetes locus in French Caucasians. The gene was sequenced in 368 type 2 diabetic case subjects with a family history of type 2 diabetes and 372 normoglycemic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.